1 2 3 4 Drosophila Importin - 7 functions upstream of the Elmo signaling module to mediate 5 the formation and stability of muscle attachments 6 7
نویسنده
چکیده
2 3 4 Drosophila Importin-7 functions upstream of the Elmo signaling module to mediate 5 the formation and stability of muscle attachments 6 7 Ze Cindy Liu, Nadia Odell and Erika R. Geisbrecht 8 9 10 11 Division of Cell Biology and Biophysics, School of Biological Sciences, University of 12 Missouri, Kansas City, MO 64110 13 Ph.D program, School of Biological Sciences, University of Missouri, Kansas City, MO 14 64110 15 16 Address all correspondence to Erika R. Geisbrecht, Ph.D. ([email protected]) 17 Phone: (816)235-6433 18 19 20 21 Running title: Elmo is required for muscle attachment 22
منابع مشابه
Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.
Establishment and maintenance of stable muscle attachments is essential for coordinated body movement. Studies in Drosophila have pioneered a molecular understanding of the morphological events in the conserved process of muscle attachment formation, including myofiber migration, muscle-tendon signaling, and stable junctional adhesion between muscle cells and their corresponding target insertio...
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The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migra...
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BACKGROUND Engulfment of apoptotic cells is important for cellular homeostasis and the development of multicellular organisms. Previous studies have shown that more than one engulfment receptors act upstream of the conserved signaling module CED-2/CrkII-CED-5/Dock180-CED-12/ELMO for cell corpse removal in C. elegans, but little is known about their identities, except for PSR-1. RESULTS We sho...
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